This distinction will depend on your business activity. 
Go to the DEA website and access Forms 224 or 225. Refer to the detailed information below for registration process, forms, fees, etc.: The DEA Registration & Renewal Fact Sheet summarizes these processes. 
This section describes how to acquire a DEA registration, renew an existing DEA registration, obtain duplicate copies of a DEA registration, and how and when to request a modification to a DEA registration. Summary of DEA Registration and Approval Process
Research Advisory Panel of California and Registration for Schedule I. Researcher and Practitioner Registration for Schedule II-V. Summary of DEA Registration and Approval Process.
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